This software was designed to make predictions on mutations falling within coding regions. It relies on the information contained in UniProtKB, where there are currently data on more than 60,000 variant proteins. The software utilizes different algorithms like TANGO (which detects regions prone to aggregation), WALTZ (which calculate the propensity of a certain region to produce amyloids) and LIMBO (which predicts chaperone binding sites for the Hsp70 chaperones).
