PROVEAN (PROtein Variation Effect ANalyzer) is an in-silico analysis tool to predict whether a missense mutation or an indel has an impact on the biological function of a protein. Like SIFT, PROVEAN is hosted by the J Craig Venter Institute, where they claim its output to be comparable to the one of other software like Polyphen2 or SIFT.
A variant of the software called PROVEAN HUMAN GENOME VARIANTS returns the results of PROVEAN and SIFT simultaneously.
