SIFT (Sorting Tolerant From Intolerant)
SIFT is an in-silico analysis tool that predicts pathogenicity based on the level of conservation of an amino acid residue across different species. The assumption is that residues which are essential for protein function must be highly conserved and that mutations affecting such residues are therefore highly likely pathogenic.
The SIFT homepage is hosted by the J Craig Venter Institute, where also the PROVEAN tool is available.
